Epitope Mapping

High-Resolution Insights for Immune Research & Diagnostics

Epitope mapping is a powerful way to analyse how antibodies recognize specific regions (epitopes) on proteins and pathogens.

By pinpointing these binding sites, researchers gain a deeper understanding of immune responses, guiding innovation in drug development, diagnostic research, and beyond.

Why Epitope Mapping Matters

Identify Immunogenic Regions: Pinpoint sites targeted by anti-drug or autoantibodies, helping to mitigate adverse effects and optimize therapeutic design.
Serological Profiling: Uncover pathogen-specific or auto-reactive antibody patterns in infectious diseases and immune disorders.
Reveal Diagnostic Insights: Discover novel biomarkers or track disease progression through precise antibody-epitope interactions.
Enhance Antibody Reliability: Validate the binding specificity of commercial or recombinant antibodies, confirming findings and increasing reliability.

Applications

Biologics Development

Minimize immunogenicity risks and refine therapeutic proteins.

Vaccine & Diagnostic Research

Assess vaccine response, characterize autoantibodies, and investigate infection responses.

Antibody Validation

Ensure reagents bind accurately to intended targets, preventing flawed data.

Autoimmune Disease

Characterise autoantibody profiles and disease mechanisms in complex conditions.

Core Capabilities

Epitope mapping on high-density peptide microarrays
Customizable arrays from protein, viral, or bacterial sequences
Up to 100,000 peptides for comprehensive epitope discovery
Standard arrays of ~1200 peptides for focused screening
Expertise in immunology and antibody characterisation

Tailored Solutions

Study design, immunological analysis & guidance
Fully customizable peptide selection
Bioinformatics & AI-guided epitope prediction
Discovery confirmation via targeted immunoassay
Peptide-ELISA diagnostic prototyping
Custom peptide design & synthesis
Ongoing technical and consultative support

Antibody Profiling

Immunoglobulins and Isotypes

IgG (total) and/or subclasses 1-4
IgM, IgA, IgE, IgD
Non-human antibodies

Motif Discovery and Specificity

Monoclonal antibody specificity
Polyclonal antibody profiling

Assay Requirements

Sample Types

Serum, plasma, dried blood spot
Saliva
Cell culture supernatant
and more...

Minimal sample

<20 µL per assay

Analysis & Bioinformatics

Robust, Quality-First Approach

World-class immunology
Microarray design from sequence
AI-guided epitope prediction
Data standardisation
Integrated quality control targets
Robust statistical analysis