Biotome's PepLock surface conjugation technology has a home: peplock.au

5 minutes ago

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Find out more at the new PepLock site: peplock.au

Since we filed the international patent application in June, PepLock has mostly lived in a few paragraphs on this site, a slide deck and a lot of conversations. That worked for a while. But the questions people ask have settled into a pattern, and it made sense to put the answers somewhere everyone can find them without waiting for one of us to reply.

The short version:

PepLock is a family of short peptide anchors that give proteins, peptides, antibodies and enzymes built-in immobilisation on solid surfaces. Think of it as protein superglue. The anchor can be built into a recombinant protein’s sequence, included during solid-phase peptide synthesis, or attached chemically. The tagged molecule attaches to its intended surface in one aqueous step, with no coupling reagents, no capture proteins and no extra tags. Your expression and purification workflow stays exactly as it is. Immobilisation becomes the last step rather than a separate chemistry project.

What is on the site:

Technology. How built-in immobilisation differs from the usual ways of getting a protein onto a surface (passive adsorption, EDC/NHS, streptavidin-biotin, His-tags, SpyTag and friends), what it withstands, and what the evidence covers.
Applications. A sector-by-sector look at where PepLock has been demonstrated and where we think it is headed.
FAQ. The questions we get asked most, answered plainly.
Work with us. How to request the data pack, or start a licensing or investment conversation.

The site describes what PepLock does and the surfaces, molecules and formats it has been demonstrated on. It stops short of the data. The data is real, and we are happy to show it, but it comes after a short conversation and an NDA. If you would like to see it, the request form is on the site.

And if you have used our Helitope kit, you have already met PepLock. Helitope RUO is its first commercial use. We used PepLock for surface conjugation, binding the Helitope peptides directly to the assay surface.

So please, take a look at peplock.au. If something is unclear or you think a question is missing from the FAQ, tell us. We would rather fix it than guess!